Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 12/20 | 0.49 |
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13590786 | 0.89 | IKBKB (0.51) | MTORSMG1JAK2JAK3JAK1 | |
| SCHEMBL8313895 | 0.88 | JAK2 (0.54) | MTORSMG1JAK2JAK3JAK1 | |
| SCHEMBL4071019 | 0.87 | IKBKB (0.56) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL8312451 | 0.87 | IKBKB (0.58) | MTORSMG1JAK2JAK3JAK1 | |
| SCHEMBL14021396 | 0.86 | IKBKB (0.56) | MTORSMG1JAK2JAK3JAK1 | |
| SCHEMBL8314813 | 0.85 | MTOR (0.54) | MTORSMG1JAK2ALDH1A1LMNA | |
| SCHEMBL8312956 | 0.85 | TSHR (0.54) | MTORSMG1JAK2ALDH1A1LMNA | |
| SCHEMBL8313300 | 0.84 | IKBKB (0.55) | MTORSMG1JAK2JAK3IKBKB | |
| SCHEMBL14021335 | 0.84 | MTOR (0.51) | MTORSMG1JAK2ALDH1A1LMNA | |
| SCHEMBL8313348 | 0.83 | SMG1 (0.48) | MTORSMG1JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |