Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 7/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.50 |
| ▸ | CHUK | O15111 | 4/20 | 0.49 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312956 | 0.94 | TSHR (0.54) | MTORSMG1ALDH1A1LMNATSHR | |
| SCHEMBL14021335 | 0.88 | MTOR (0.51) | MTORSMG1ALDH1A1LMNATSHR | |
| SCHEMBL14020977 | 0.88 | JAK2 (0.58) | MTORSMG1IKBKBCAMK2DCHUK | |
| SCHEMBL8314825 | 0.88 | MTOR (0.57) | MTORSMG1LMNAIKBKBCAMK2D | |
| SCHEMBL8314809 | 0.88 | MTOR (0.57) | MTORSMG1IKBKBCAMK2DCHUK | |
| SCHEMBL4071019 | 0.87 | IKBKB (0.56) | TSHRIKBKBCHUKMAPK8MAPK10 | |
| SCHEMBL14021618 | 0.87 | HTT (0.54) | ALDH1A1LMNATSHRNPSR1HTT | |
| SCHEMBL14021252 | 0.87 | ALDH1A1 (0.62) | ALDH1A1LMNATSHRNPSR1SMN1; SMN2 | |
| SCHEMBL14063912 | 0.86 | IKBKB (0.64) | MTORSMG1IKBKBCAMK2DCHUK | |
| SCHEMBL8312206 | 0.85 | MTOR (0.50) | MTORSMG1ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |