Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095667 | 0.85 | CCR1 (0.39) | CYP2D6MEN1KMT2ACCR1ALDH1A1 | |
| SCHEMBL6095673 | 0.85 | CCR1 (0.39) | CYP2D6MEN1KMT2ACCR1ALDH1A1 | |
| SCHEMBL6274732 | 0.84 | CCR3 (0.34) | CCR1ALDH1A1 | |
| SCHEMBL6095902 | 0.83 | CCR1 (0.38) | CCR1OPRD1OPRK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6095898 | 0.83 | CCR1 (0.38) | CCR1OPRD1OPRK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6841776 | 0.82 | BCHE (0.33) | CCR1 | |
| SCHEMBL6098489 | 0.79 | DRD4 (0.36) | CCR1ALDH1A1 | |
| SCHEMBL6098492 | 0.79 | DRD4 (0.36) | CCR1ALDH1A1 | |
| SCHEMBL8306421 | 0.79 | DRD4 (0.36) | CCR1ALDH1A1 | |
| SCHEMBL8307328 | 0.78 | SLC6A2 (0.36) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004080460-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |