Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 9/20 | 0.50 |
| ▸ | CHUK | O15111 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308878 | 0.95 | CDK1 (0.53) | CDK1PIK3CAPIK3CBPIK3CGIKBKB | |
| SCHEMBL8254568 | 0.90 | JAK2 (0.55) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL4074601 | 0.90 | IKBKB (0.50) | CDK1PIK3CAPIK3CBPIK3CGIKBKB | |
| SCHEMBL13590857 | 0.90 | CDK1 (0.54) | CDK1PIK3CAPIK3CBPIK3CGIKBKB | |
| SCHEMBL11924743 | 0.89 | GRM5 (0.60) | CDK1PIK3CAPIK3CBPIK3CGIKBKB | |
| SCHEMBL4396304 | 0.89 | IKBKB (0.53) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| Hydrochloric Acid SCHEMBL4071661 | 0.89 | CDK1 (0.53) | CDK1PIK3CAPIK3CBPIK3CGIKBKB | |
| Hydrochloric Acid SCHEMBL4066207 | 0.88 | IKBKB (0.53) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL8258444 | 0.88 | IKBKB (0.50) | CDK1PIK3CAPIK3CBPIK3CGIKBKB | |
| SCHEMBL14021219 | 0.88 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CGIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |