Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.67 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29662886 | 0.98 | ESR2 (0.69) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL223 | 0.98 | ESR2 (0.69) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| Water SCHEMBL3178714 | 0.98 | ESR2 (0.69) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| Hydrochloric Acid SCHEMBL6985442 | 0.95 | ESR2 (0.67) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| Fluoride SCHEMBL27583847 | 0.95 | ESR2 (0.67) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| Bromide SCHEMBL27774142 | 0.95 | ESR2 (0.67) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2016996 | 0.93 | ESR2 (0.70) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| Ethylene SCHEMBL28042734 | 0.93 | ESR2 (0.64) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27895577 | 0.93 | ESR2 (0.69) | ESR2GABRG2GABRB3GABRA5GABRA3 | |
| Methylamine SCHEMBL3181738 | 0.91 | ESR2 (0.62) | ESR2GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120225896-A1 | NOVEL 2-PYRIDONE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | KOWA COMPANY, LTD. (JP) | 2012-09-06 | — | — | US | disclosed |
| EP-0628046-B1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | UNION PHARMA SCIENT APPL (FR) | 1999-05-12 | — | — | EP | disclosed |
| EP-0628046-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628045-A1 | PYRAZOLOPYRIMIDIN DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993017023-A1 | PYRAZOLOPYRIMIDIN DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |
| WO-1993017024-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225896-A1 | NOVEL 2-PYRIDONE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | PPARG, PPARD, PPARA | ESR2 796/4885GABRG2 1013/4885GABRB3 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.