Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 2/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314597 | 0.89 | AVPR2 (0.46) | AVPR2AVPR1A | |
| SCHEMBL7333034 | 0.87 | NAMPT (0.44) | AVPR2AVPR1A | |
| SCHEMBL7344569 | 0.85 | AVPR2 (0.65) | AVPR2AVPR1A | |
| SCHEMBL8315962 | 0.84 | AVPR2 (0.45) | AVPR2AVPR1A | |
| SCHEMBL8312897 | 0.84 | AVPR2 (0.54) | AVPR2AVPR1A | |
| SCHEMBL8317730 | 0.83 | AVPR1A (0.47) | AVPR2AVPR1ATHRBKCNJ5KCNJ3 | |
| SCHEMBL8314671 | 0.83 | AVPR2 (0.47) | AVPR2AVPR1ATHRBKCNJ5KCNJ3 | |
| SCHEMBL8556372 | 0.82 | KCNJ5 (0.51) | AVPR2AVPR1ATHRBKCNJ5KCNJ3 | |
| SCHEMBL8559196 | 0.82 | THRB (0.55) | THRBKCNJ5KCNJ3 | |
| SCHEMBL8314472 | 0.81 | AVPR2 (0.51) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636625-B1 | Tricyclic diazepines vasopressin and oxytocin antagonists | AMERICAN CYANAMID CO (US) | 1999-01-27 | — | — | EP | disclosed |