Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.54 |
| ▸ | CHUK | O15111 | 14/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311423 | 0.87 | IKBKB (0.67) | IKBKBCHUKMTORSMG1 | |
| SCHEMBL8312614 | 0.87 | IKBKB (0.66) | IKBKBCHUKMTORSMG1JAK2 | |
| SCHEMBL8311421 | 0.87 | IKBKB (0.66) | IKBKBCHUKMTORSMG1JAK2 | |
| SCHEMBL14063888 | 0.86 | IKBKB (0.63) | IKBKBCHUKKMT2A | |
| SCHEMBL8308729 | 0.85 | IKBKB (0.61) | IKBKBCHUKMTORSMG1IKBKG | |
| SCHEMBL8308545 | 0.85 | IKBKB (0.69) | IKBKBCHUKMTORSMG1 | |
| SCHEMBL8312950 | 0.85 | IKBKB (0.57) | IKBKBCHUKMTORSMG1TDP1 | |
| SCHEMBL8313896 | 0.84 | IKBKB (0.63) | IKBKBCHUKMTORSMG1JAK2 | |
| SCHEMBL14063903 | 0.84 | MTOR (0.53) | IKBKBCHUKMTORSMG1JAK2 | |
| SCHEMBL8312528 | 0.83 | IKBKB (0.57) | IKBKBCHUKMTORSMG1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |