Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.35 |
| ▸ | FYN | P06241 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5389872 | 0.81 | DYRK1A (0.38) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL5389145 | 0.81 | CLK4 (0.41) | — | |
| SCHEMBL5389869 | 0.77 | FYN (0.37) | FYN | |
| SCHEMBL3342646 | 0.75 | MAP4K4 (0.42) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL5097619 | 0.75 | KMT2A (0.40) | FYNMEN1CYP3A4MKNK1POLB | |
| SCHEMBL22353993 | 0.72 | MAPK14 (0.40) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL980384 | 0.67 | PIK3CD (0.50) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL23142760 | 0.67 | MAOA (0.52) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL16386822 | 0.66 | DDB1 (0.42) | CDK5CDK5R1ALDH1A1CYP3A4RECQL | |
| SCHEMBL29979572 | 0.66 | TSHR (0.53) | DYRK3CCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089911-A1 | PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |