Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6083239 | 1.00 | POLB (0.34) | POLBATMAAK1BRD9ELANE | |
| SCHEMBL6081924 | 1.00 | POLB (0.34) | POLBATMAAK1BRD9ELANE | |
| SCHEMBL6081853 | 0.85 | AAK1 (0.30) | AAK1 | |
| SCHEMBL6081991 | 0.85 | AAK1 (0.30) | AAK1 | |
| SCHEMBL8317430 | 0.77 | CYP4F2 (0.44) | ALDH1A1NFKB1NFKB2RELACYP1A2 | |
| SCHEMBL8318115 | 0.73 | ELANE (0.32) | BRD9ELANECTRB1LMNANPSR1 | |
| SCHEMBL6083248 | 0.73 | ELANE (0.32) | BRD9ELANECTRB1LMNANPSR1 | |
| SCHEMBL6081926 | 0.73 | ELANE (0.32) | BRD9ELANECTRB1LMNANPSR1 | |
| SCHEMBL8313324 | 0.72 | ELANE (0.33) | AAK1ELANECTRB1 | |
| SCHEMBL6082596 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5750556-A | REDUCING DOPAMINE SYNTHESIS AND RELEASE, SCHIZOPHRENIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |