Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | PER2 | O15055 | 2/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 2/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316786 | 0.83 | PSEN1 (0.43) | KDM4ERECQLOPRL1BRD4CREBBP | |
| SCHEMBL8317223 | 0.80 | PSEN1 (0.45) | KDM4ERECQLOPRL1BRD4CREBBP | |
| SCHEMBL8318351 | 0.78 | PSEN1 (0.47) | OPRL1BRD4CREBBPMMP13OPRM1 | |
| SCHEMBL2603740 | 0.78 | KDM4E (0.47) | KDM4ERECQLOPRL1BRD4CREBBP | |
| SCHEMBL8314425 | 0.76 | KDM4E (0.40) | KDM4ERECQLOPRL1BRD4CREBBP | |
| SCHEMBL3286860 | 0.75 | MMP13 (0.38) | KDM4EOPRL1BRD4CREBBPMMP13 | |
| SCHEMBL3288638 | 0.75 | MMP13 (0.38) | OPRL1BRD4CREBBPMMP13PSEN1 | |
| SCHEMBL904865 | 0.74 | BRD4 (0.49) | KDM4ERECQLOPRL1BRD4CREBBP | |
| SCHEMBL8315075 | 0.73 | BRD4 (0.41) | KDM4ERECQLOPRL1BRD4CREBBP | |
| SCHEMBL7850153 | 0.73 | ATM (0.57) | ATMPER2CRY1CRY2CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |