Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | GALR2 | O43603 | 1/20 | 0.48 |
| ▸ | GALR1 | P47211 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998709 | 0.95 | BRAF (0.50) | SYKEGFRERBB2HPGDHTT | |
| SCHEMBL6998715 | 0.95 | BRAF (0.50) | SYKEGFRERBB2HPGDHTT | |
| SCHEMBL6993308 | 0.88 | BRAF (0.48) | SYKEGFRERBB2HPGDHTT | |
| SCHEMBL6993311 | 0.88 | BRAF (0.48) | SYKEGFRERBB2HPGDHTT | |
| SCHEMBL8312571 | 0.87 | CSNK2A1 (0.60) | SYKEGFRERBB2HPGDHTT | |
| SCHEMBL8317346 | 0.85 | EGFR (0.51) | EGFRERBB2HPGDHTTCTSC | |
| SCHEMBL8318987 | 0.85 | CTSC (0.61) | EGFRERBB2HPGDHTTCTSC | |
| SCHEMBL8317921 | 0.84 | BRAF (0.52) | EGFRERBB2HPGDHTTGALR2 | |
| SCHEMBL8317917 | 0.84 | BRAF (0.52) | EGFRERBB2HPGDHTTGALR2 | |
| SCHEMBL8317928 | 0.83 | EGFR (0.60) | EGFRERBB2HPGDHTTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |