Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312571 | 0.88 | CSNK2A1 (0.60) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314012 | 0.85 | SYK (0.53) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994609 | 0.83 | BRAF (0.51) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994605 | 0.83 | BRAF (0.51) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8318072 | 0.82 | EGFR (0.71) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8317928 | 0.82 | EGFR (0.60) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7142831 | 0.82 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8316916 | 0.82 | EGFR (0.55) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8319428 | 0.82 | EGFR (0.73) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8316032 | 0.82 | EGFR (0.72) | EGFRERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0781284-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1997-07-02 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996008494-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1996-03-21 | — | — | WO | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |