Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.49 |
| ▸ | ACE | P12821 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 8/20 | 0.44 |
| ▸ | LCK | P06239 | 9/20 | 0.40 |
| ▸ | IL1B | P01584 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314071 | 0.87 | ACE (0.46) | MMEACE | |
| SCHEMBL8312768 | 0.87 | ACE (0.46) | MMEACE | |
| SCHEMBL7356109 | 0.86 | ACE (0.66) | MMEACECASP1LCKIL1B | |
| SCHEMBL7380917 | 0.82 | ACE (0.65) | MMEACECASP1LCKIL1B | |
| SCHEMBL10373357 | 0.79 | ACE (0.53) | MMEACECASP1LCK | |
| SCHEMBL10368190 | 0.78 | ACE (0.58) | ACE | |
| SCHEMBL10367834 | 0.78 | ACE (0.58) | ACE | |
| SCHEMBL8315371 | 0.77 | MME (0.56) | MMEACECASP1LCK | |
| SCHEMBL7384249 | 0.77 | ACE (0.55) | MMEACECASP1LCKIL1B | |
| SCHEMBL10367210 | 0.76 | ACE (0.50) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640086-B1 | MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 1999-08-04 | — | — | EP | claimed |