Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.55 |
| ▸ | MME | P08473 | 5/20 | 0.55 |
| ▸ | CASP1 | P29466 | 5/20 | 0.41 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356109 | 0.91 | ACE (0.66) | ACEMMECASP1IL1BLCK | |
| SCHEMBL7380917 | 0.85 | ACE (0.65) | ACEMMECASP1IL1BLCK | |
| SCHEMBL7382519 | 0.85 | ACE (0.42) | ACEMME | |
| SCHEMBL8314652 | 0.85 | ACE (0.64) | ACEMME | |
| SCHEMBL7348133 | 0.85 | ACE (0.64) | ACEMME | |
| SCHEMBL7381909 | 0.84 | ACE (0.55) | ACEMMEEPHX2 | |
| SCHEMBL7379670 | 0.84 | ACE (0.55) | ACEMMEEPHX2 | |
| SCHEMBL7378088 | 0.84 | ACE (0.60) | ACEMME | |
| SCHEMBL7350509 | 0.78 | ACE (0.35) | ACEMMEEPHX2 | |
| SCHEMBL8314075 | 0.77 | MME (0.49) | ACEMMECASP1IL1BLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640086-A1 | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO 1,2]PYRIDAZINE, PYRAZOLO 1,2]PYRIDAZINE, PYRIDAZO 1,2-a] 1,2]DIAZEPINE AND PYRAZOLO 1,2-a] 1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5366973-A | Enkephalinase inhibitors, bradykinin inhibitors or inhibitors of angiotensin converting enzymes as analgesics, diuretics or hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-22 | — | — | US | disclosed |
| WO-1993023403-A1 | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-25 | — | — | WO | disclosed |