SCHEMBL8314256

SCHEMBL8314256

CCCc1c(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c(O)nc2ncnn12

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC33A1 O00400 18/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7932757 0.95 SLC33A1 (0.45) SLC33A1
SCHEMBL9256744 0.93 SLC33A1 (0.38) SLC33A1
SCHEMBL9253560 0.91 SLC33A1 (0.36) SLC33A1
SCHEMBL9254444 0.90 SLC33A1 (0.48) SLC33A1
SCHEMBL9251346 0.90 SLC33A1 (0.37) SLC33A1
SCHEMBL9256912 0.90 SLC33A1 (0.46) SLC33A1
SCHEMBL9257779 0.90 SLC33A1 (0.46) SLC33A1
SCHEMBL9253961 0.90 SLC33A1 (0.46) SLC33A1
SCHEMBL9256561 0.89 SLC33A1 (0.37) SLC33A1
SCHEMBL9255130 0.87 USP2 (0.39) SLC33A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0628046-B1 TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS UNION PHARMA SCIENT APPL (FR) 1999-05-12 EP claimed
US-5387747-A Used in the treatment and prevention of cardiovascular diseases: hypertension, cardiac insufficiency and atherosclerosis LABORATOIRES UPSA (FR) 1995-02-07 US disclosed