SCHEMBL7932757

SCHEMBL7932757

CCCCc1c(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c(O)nc2ncnn12

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC33A1 O00400 15/20 0.45
AGTR1 P30556 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8314256 0.95 SLC33A1 (0.46) SLC33A1
SCHEMBL9256744 0.91 SLC33A1 (0.38) SLC33A1
SCHEMBL9253560 0.89 SLC33A1 (0.36) SLC33A1
SCHEMBL9256922 0.87 SLC33A1 (0.43) SLC33A1AGTR1
SCHEMBL9256561 0.87 SLC33A1 (0.37) SLC33A1
SCHEMBL9255130 0.86 USP2 (0.39) SLC33A1
SCHEMBL9254444 0.85 SLC33A1 (0.48) SLC33A1
SCHEMBL9251346 0.85 SLC33A1 (0.37) SLC33A1
SCHEMBL9253961 0.84 SLC33A1 (0.46) SLC33A1
SCHEMBL9257779 0.84 SLC33A1 (0.46) SLC33A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6218414-B1 ADMINISTERING AN EFFECTIVE AMOUNT OF AN ANGIOTENSIN II ANTAGONIST AND A BENZOFURAN DERIVATIVE WITH ANTIARRHYTHMIC ACTIVITY FOR THERAPY OF CARDIOVASCULAR COMPLAINTS SANOFI (FR) 2001-04-17 US disclosed
EP-0752249-A2 Use of an angiotensin II antagonist and a benzofurane derivative having antiarithmic activity for the manufacture of a medicament for the treatment of cardiovascular disorders SANOFI (FR) 1997-01-08 EP disclosed
US-5387747-A Used in the treatment and prevention of cardiovascular diseases: hypertension, cardiac insufficiency and atherosclerosis LABORATOIRES UPSA (FR) 1995-02-07 US disclosed