Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316477 | 0.89 | BRAF (0.64) | BRAFEGFRLMNA | |
| SCHEMBL6995917 | 0.89 | BRAF (0.54) | BRAFEGFR | |
| SCHEMBL8316744 | 0.86 | BRAF (0.54) | BRAFEGFR | |
| SCHEMBL8318927 | 0.86 | LMNA (0.54) | BRAFEGFRLMNA | |
| SCHEMBL8320421 | 0.86 | EGFR (0.65) | BRAFEGFRLMNA | |
| SCHEMBL8318487 | 0.86 | EGFR (0.65) | BRAFEGFR | |
| SCHEMBL6998863 | 0.85 | EGFR (0.54) | BRAFEGFRMKNK2 | |
| SCHEMBL8314169 | 0.85 | EGFR (0.64) | BRAFEGFRLMNA | |
| SCHEMBL8313771 | 0.83 | EGFR (0.65) | BRAFEGFRLMNA | |
| SCHEMBL8314998 | 0.83 | BRAF (0.51) | BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |