Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.45 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319127 | 0.89 | EGFR (0.54) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317514 | 0.89 | EGFR (0.54) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8319040 | 0.89 | EGFR (0.54) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6995363 | 0.86 | EGFR (0.55) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8315925 | 0.85 | EGFR (0.55) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994345 | 0.84 | EGFR (0.53) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6989432 | 0.84 | STK17A (0.62) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317956 | 0.84 | EGFR (0.56) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6990324 | 0.84 | STK17A (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6999279 | 0.83 | EGFR (0.56) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |