Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651466 | 0.68 | EGFR (0.36) | EGFR | |
| SCHEMBL4987651 | 0.66 | KDM4E (0.38) | RPS6KA3EGFR | |
| SCHEMBL3191645 | 0.65 | ENPP2 (0.54) | EGFRENPP2 | |
| SCHEMBL8313715 | 0.65 | PTPN11 (0.48) | EGFR | |
| SCHEMBL14656791 | 0.64 | KDM4E (0.38) | EGFR | |
| SCHEMBL14506729 | 0.64 | PIK3CA (0.35) | MAPKAPK2RPS6KA3CSNK2A1PLK3EGFR | |
| SCHEMBL10276914 | 0.64 | HTT (0.35) | — | |
| SCHEMBL18150491 | 0.64 | GSK3A (0.40) | EGFR | |
| SCHEMBL31344848 | 0.61 | DYRK1A (0.33) | — | |
| SCHEMBL30548526 | 0.61 | DYRK1A (0.33) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |