Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.67 |
| ▸ | CLK1 | P49759 | 2/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.67 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | CDK9 | P50750 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 3/20 | 0.60 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745264 | 0.84 | CDK8 (0.72) | CDK8NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL18576768 | 0.83 | NTRK1 (1.00) | CDK8NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL3761982 | 0.82 | DYRK1A (0.75) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL3771378 | 0.81 | SGK1 (0.70) | CDK8NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL3764839 | 0.81 | AXL (0.83) | CDK8NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL3767902 | 0.80 | MAP3K11 (0.70) | CDK8NTRK1DYRK1AMAP3K11CCNT1 | |
| SCHEMBL12763233 | 0.79 | CDK8 (0.76) | CDK8NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL20564684 | 0.79 | CDK8 (0.67) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL722564 | 0.79 | MAP3K11 (1.00) | CDK8NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL3770685 | 0.78 | AXL (0.72) | CDK8NTRK1DYRK1ACLK1DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |