Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.64 |
| ▸ | MME | P08473 | 6/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348133 | 1.00 | ACE (0.64) | ACEMMEAPPF2LTA4H | |
| SCHEMBL7378088 | 0.97 | ACE (0.60) | ACEMMEAPPF2LTA4H | |
| SCHEMBL7379670 | 0.93 | ACE (0.55) | ACEMMEAPPLTA4H | |
| SCHEMBL7381909 | 0.93 | ACE (0.55) | ACEMMEAPPLTA4H | |
| SCHEMBL8313993 | 0.86 | ACE (0.61) | ACEMMEAPP | |
| SCHEMBL7356109 | 0.86 | ACE (0.66) | ACEMME | |
| SCHEMBL7384249 | 0.85 | ACE (0.55) | ACEMME | |
| SCHEMBL8312768 | 0.85 | ACE (0.46) | ACEMMEF2 | |
| SCHEMBL8314071 | 0.85 | ACE (0.46) | ACEMMEF2 | |
| SCHEMBL7356825 | 0.84 | ACE (0.49) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640086-B1 | MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 1999-08-04 | — | — | EP | claimed |
| US-5366973-A | Enkephalinase inhibitors, bradykinin inhibitors or inhibitors of angiotensin converting enzymes as analgesics, diuretics or hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-22 | — | — | US | claimed |
| EP-0640086-B1 | MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 1999-08-04 | — | — | EP | disclosed |
| US-5366973-A | Enkephalinase inhibitors, bradykinin inhibitors or inhibitors of angiotensin converting enzymes as analgesics, diuretics or hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-22 | — | — | US | disclosed |