Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 7/20 | 0.54 |
| ▸ | CHUK | O15111 | 5/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314809 | 0.93 | MTOR (0.57) | MTORSMG1CDK1CDK2IKBKB | |
| SCHEMBL14020977 | 0.89 | JAK2 (0.58) | MTORSMG1IKBKBCHUKCAMK2D | |
| SCHEMBL14063912 | 0.89 | IKBKB (0.64) | MTORSMG1IKBKBCHUKCAMK2D | |
| SCHEMBL8314813 | 0.88 | MTOR (0.54) | MTORSMG1IKBKBCHUKCAMK2D | |
| SCHEMBL8311095 | 0.87 | MTOR (0.50) | MTORSMG1CDK1CDK2IKBKB | |
| SCHEMBL14063914 | 0.87 | SYK (0.52) | MTORSMG1CDK1CDK2IKBKB | |
| SCHEMBL14021571 | 0.85 | CDK1 (0.66) | CDK1CDK2IKBKBCHUKCAMK2D | |
| SCHEMBL8311426 | 0.85 | IKBKB (0.56) | MTORSMG1CDK1CDK2IKBKB | |
| SCHEMBL8308666 | 0.85 | IKBKB (0.65) | CDK1CDK2IKBKBCHUKJAK2 | |
| SCHEMBL8312148 | 0.84 | CDK1 (0.62) | CDK1CDK2IKBKBCHUKCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |