Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 13/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171077 | 0.81 | GRIN2B (0.64) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7506582 | 0.81 | SMN1; SMN2 (0.62) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5806087 | 0.81 | SMN1; SMN2 (0.65) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL23235688 | 0.80 | HCAR2 (0.47) | MEN1KMT2A | |
| SCHEMBL19404905 | 0.78 | SMN1; SMN2 (0.57) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL20835999 | 0.78 | GPR119 (0.56) | MEN1KMT2A | |
| SCHEMBL7503270 | 0.78 | MEN1 (0.64) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4035554 | 0.78 | SMN1; SMN2 (0.72) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL27604920 | 0.78 | SMN1; SMN2 (0.52) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2896415 | 0.77 | SMN1; SMN2 (0.76) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |