Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315278 | 1.00 | EGFR (0.60) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8317946 | 0.93 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8317943 | 0.93 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8457936 | 0.90 | EGFR (0.53) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8314526 | 0.90 | EGFR (0.60) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8457941 | 0.90 | EGFR (0.53) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8314519 | 0.90 | EGFR (0.60) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8318556 | 0.89 | CSNK2A1 (0.54) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8315560 | 0.88 | EGFR (0.46) | EGFRERBB2HPGDHTTCCNE1 | |
| SCHEMBL8315561 | 0.88 | EGFR (0.46) | EGFRERBB2HPGDHTTCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |