Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315561 | 1.00 | EGFR (0.46) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8318014 | 0.93 | MAPK10 (0.47) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8318017 | 0.93 | MAPK10 (0.47) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8317605 | 0.88 | ABCG2 (0.50) | EGFRERBB2HPGDHTTABCG2 | |
| SCHEMBL8315278 | 0.88 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8315282 | 0.88 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8314526 | 0.88 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8457936 | 0.88 | EGFR (0.53) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8314519 | 0.88 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPK10 | |
| SCHEMBL8457941 | 0.88 | EGFR (0.53) | EGFRERBB2HPGDHTTMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |