SCHEMBL8315308

SCHEMBL8315308

O=C1C(Cl)=C(Cl)C(=O)N1CC1CCCCC1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 4/20 0.48
CHRM5 P08912 2/20 0.40
ADRA2C P18825 1/20 0.40
CHRM2 P08172 1/20 0.40
CHRM4 P08173 1/20 0.40
CHRM1 P11229 1/20 0.40
TRPA1 O75762 2/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP19A1 P11511 2/20 0.38
BLM P54132 1/20 0.38
WRN Q14191 1/20 0.38
OPRL1 P41146 1/20 0.36
ACHE P22303 1/20 0.35
CEL P19835 1/20 0.35
HSD11B1 P28845 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31236808 0.76 DUSP3 (0.45) CYP1B1TRPA1HTT
SCHEMBL30657539 0.75 CYP1B1 (0.62) CYP1B1TRPA1MAPK1HTTOPRL1
SCHEMBL8247166 0.75 CYP1B1 (0.62) CYP1B1TRPA1MAPK1HTTOPRL1
SCHEMBL19091274 0.74 CHRM5 (0.43) CYP1B1CHRM5ADRA2CCHRM2CHRM4
SCHEMBL21419553 0.72 CYP1B1 (0.45) CYP1B1CHRM5ADRA2CCHRM2CHRM4
SCHEMBL1275809 0.72 CYP1B1 (0.45) CYP1B1CHRM5ADRA2CCHRM2CHRM4
SCHEMBL19176752 0.72 CYP1B1 (0.45) CYP1B1CHRM5ADRA2CCHRM2CHRM4
SCHEMBL24444389 0.71 KMT2A (0.36) CHRM5ADRA2CCHRM2CHRM4CHRM1
SCHEMBL3265836 0.69 CYP19A1 (0.40) CYP1B1CHRM5ADRA2CCHRM2CHRM4
SCHEMBL13291893 0.69 ACHE (0.43) CYP1B1CHRM5ADRA2CCHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630242-B1 FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY WELLCOME FOUND (GB) 1999-01-20 EP disclosed
US-5547976-A VIRICIDES, HERPES VIRUS, CYTOMEGALOVIRUS; CARDIOVASCULAR DISORDERS BURROUGHS WELLCOME CO. (US) 1996-08-20 US disclosed
EP-0630241-A1 INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY THE WELLCOME FOUNDATION LIMITED (GB) 1994-12-28 EP disclosed
EP-0630242-A1 FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY THE WELLCOME FOUNDATION LIMITED (GB) 1994-12-28 EP disclosed
WO-1993018766-A1 FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY THE WELLCOME FOUNDATION LIMITED (GB) 1993-09-30 WO disclosed
WO-1993018765-A1 INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY THE WELLCOME FOUNDATION LIMITED (GB) 1993-09-30 WO disclosed