Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17931472 | 0.87 | EGFR (1.00) | EGFRERBB2MAPK1KDM4E | |
| SCHEMBL4365259 | 0.84 | EGFR (0.71) | EGFRERBB2LMNA | |
| Hydrochloric Acid SCHEMBL7665624 | 0.83 | EGFR (0.70) | EGFRERBB2LMNA | |
| SCHEMBL8522893 | 0.81 | EGFR (0.72) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL4525877 | 0.80 | EGFR (0.71) | EGFRERBB2LMNA | |
| Hydrochloric Acid SCHEMBL6207449 | 0.79 | EGFR (0.70) | EGFRERBB2LMNA | |
| SCHEMBL8871863 | 0.78 | EGFR (0.82) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8871418 | 0.77 | EGFR (0.71) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8315139 | 0.77 | EGFR (0.55) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL3391554 | 0.75 | EGFR (1.00) | EGFRERBB2MAPK1HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | claimed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | claimed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | claimed |
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | disclosed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |