Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315445 | 0.81 | EGFR (0.77) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8310883 | 0.74 | EGFR (0.66) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL13514653 | 0.72 | EGFR (0.45) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL4347143 | 0.72 | EGFR (0.61) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL18731437 | 0.71 | LMNA (0.47) | HTT | |
| SCHEMBL8871648 | 0.71 | EGFR (0.78) | EGFRERBB2MAPK1HIF1A | |
| Bromide SCHEMBL8871028 | 0.71 | EGFR (0.60) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8870421 | 0.71 | EGFR (0.66) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8315324 | 0.70 | EGFR (0.61) | EGFRERBB2MAPK1 | |
| SCHEMBL8871863 | 0.70 | EGFR (0.82) | EGFRERBB2MAPK1HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | disclosed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |