Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28043813 | 0.84 | PARP1 (0.44) | PARP1MEN1KMT2AALDH1A1NR1H2 | |
| SCHEMBL29289211 | 0.84 | PARP1 (0.44) | PARP1MEN1KMT2AALDH1A1NR1H2 | |
| SCHEMBL27722775 | 0.82 | PARP1 (0.45) | PARP1HSD17B10KDM4EMAPTTHRB | |
| SCHEMBL27717164 | 0.82 | PARP1 (0.45) | PARP1HSD17B10KDM4EMAPTTHRB | |
| SCHEMBL18789978 | 0.80 | PARP1 (0.41) | PARP1ALDH1A1HSD17B10 | |
| SCHEMBL28135174 | 0.79 | PARP1 (0.44) | PARP1HSD17B10KDM4EMAPTTHRB | |
| SCHEMBL28094553 | 0.79 | PARP1 (0.44) | PARP1HSD17B10KDM4EMAPTTHRB | |
| SCHEMBL6541621 | 0.79 | PARP1 (0.43) | PARP1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7054243 | 0.79 | PARP1 (0.43) | PARP1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7056396 | 0.79 | PARP1 (0.43) | PARP1MEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623615-B1 | Substituted 1-phenyl-oxazolidin-2-one derivatives, their preparation and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 1999-06-30 | — | — | EP | disclosed |
| EP-0623615-A1 | Adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1994-11-09 | — | — | EP | disclosed |