Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.44 |
| ▸ | CHUK | O15111 | 3/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308375 | 0.89 | JAK2 (0.47) | HTTJAK2CDK2IKBKBCHUK | |
| SCHEMBL14063867 | 0.89 | JAK2 (0.46) | JAK2CDK2CDK9IKBKBCHUK | |
| SCHEMBL14063857 | 0.88 | IKBKB (0.49) | HTTJAK2CDK2CCNT1CCNA2 | |
| SCHEMBL14021072 | 0.87 | IKBKB (0.46) | HTTJAK2CDK2IKBKBCHUK | |
| SCHEMBL4070513 | 0.87 | IKBKB (0.48) | HTTJAK2CDK2IKBKBCHUK | |
| SCHEMBL8315467 | 0.86 | IKBKB (0.52) | JAK2IKBKBCHUKIKBKGPLK4 | |
| SCHEMBL8308567 | 0.85 | IKBKB (0.50) | JAK2CDK2IKBKBCHUKIKBKG | |
| SCHEMBL14021618 | 0.84 | HTT (0.54) | HTTJAK2CDK2IKBKBCHUK | |
| SCHEMBL8313889 | 0.84 | IKBKB (0.44) | HTTJAK2CDK2CCNT1CCNA2 | |
| SCHEMBL8308468 | 0.84 | SYK (0.47) | JAK2CDK2IKBKBCHUKIKBKG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |