Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.52 |
| ▸ | CHUK | O15111 | 11/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308477 | 0.92 | IKBKB (0.46) | IKBKBCHUKIKBKGJAK2PLK4 | |
| SCHEMBL14063867 | 0.91 | JAK2 (0.46) | IKBKBCHUKIKBKGJAK2PLK4 | |
| SCHEMBL8308567 | 0.89 | IKBKB (0.50) | IKBKBCHUKIKBKGJAK2PLK4 | |
| SCHEMBL8312555 | 0.88 | IKBKB (0.52) | IKBKBCHUKMKNK1IKBKGMKNK2 | |
| SCHEMBL14063856 | 0.88 | IKBKB (0.53) | IKBKBCHUKMKNK1MKNK2JAK2 | |
| SCHEMBL8315465 | 0.86 | HTT (0.46) | IKBKBCHUKIKBKGJAK2PLK4 | |
| SCHEMBL8165798 | 0.86 | IKBKB (0.51) | IKBKBCHUKMKNK1IKBKGMKNK2 | |
| SCHEMBL8308468 | 0.86 | SYK (0.47) | IKBKBCHUKIKBKGJAK2PLK4 | |
| SCHEMBL8314446 | 0.85 | IKBKB (0.51) | IKBKBCHUKMKNK1IKBKGMKNK2 | |
| SCHEMBL14063873 | 0.84 | SYK (0.47) | IKBKBCHUKIKBKGJAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |