Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387922 | 0.88 | GRIN2D (0.40) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7847268 | 0.85 | GRIN2D (0.38) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL1387540 | 0.84 | PDE2A (0.42) | — | |
| SCHEMBL1388118 | 0.83 | GRIN2D (0.41) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL1388184 | 0.80 | CCKBR (0.40) | — | |
| SCHEMBL1387825 | 0.77 | — | — | |
| SCHEMBL1387813 | 0.71 | PDE2A (0.43) | — | |
| SCHEMBL7850567 | 0.69 | PDE2A (0.43) | — | |
| SCHEMBL7408950 | 0.69 | — | — | |
| SCHEMBL1388119 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | disclosed |
| EP-0708774-A1 | IMIDAZO [1,2-A]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002601-A1 | IMIDAZO[1,2-a]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-01-26 | — | — | WO | disclosed |