SCHEMBL8315703

SCHEMBL8315703

[CH2]CCSc1nnnn1C

nearest known ligand 0.64

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.64
TP53 P04637 3/20 0.47
LMNA P02545 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HSD17B10 Q99714 2/20 0.47
THRB P10828 1/20 0.46
CYP3A4 P08684 1/20 0.44
CYP2C19 P33261 1/20 0.44
POLB P06746 1/20 0.43
ALOX15 P16050 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10974031 0.87 ALDH1A1 (0.75) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL8316978 0.83
SCHEMBL10969206 0.83 ALDH1A1 (0.69) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL10970753 0.83 ALDH1A1 (0.69) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL18272456 0.82 ALDH1A1 (0.67) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL10969480 0.82 ALDH1A1 (0.67) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL10970972 0.82 ALDH1A1 (0.67) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL10975385 0.82 ALDH1A1 (0.67) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL11118817 0.80 ALDH1A1 (0.64) ALDH1A1TP53LMNASMN1; SMN2HSD17B10
SCHEMBL9053738 0.80 ALDH1A1 (0.64) ALDH1A1TP53LMNASMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0093376-B2 1-Sulfo-2-azetidinone derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-04-07 EP disclosed
EP-0093376-B1 1-SULFO-2-AZETIDINONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1990-03-21 EP disclosed
US-4822788-A MICROBIOCIDES, BETA-LACTAMASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-04-18 US disclosed
US-4822790-A ANTIMICROBIOCIDES OR BETA-LACTAMASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-04-18 US disclosed
US-4782147-A ANTIBIOTIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-11-01 US disclosed
US-4675397-A MICROBIOCIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-06-23 US disclosed
US-4665067-A BACTERICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-05-12 US disclosed
US-4550105-A BETA-LACTAMASE INHIBITORS, ANTIBIOTICS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-10-29 US disclosed
EP-0093376-A2 1-Sulfo-2-azetidinone derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1983-11-09 EP disclosed
EP-0053816-A1 1-Sulfo-2-oxoazetidine derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1982-06-16 EP disclosed