Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | CTSC | P53634 | 5/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315093 | 0.83 | EGFR (0.50) | EGFRHTTKDM4EMAPT | |
| SCHEMBL8319601 | 0.81 | EGFR (0.60) | EGFRTSHRHTTKDM4EPOLB | |
| SCHEMBL8318036 | 0.81 | EGFR (0.60) | EGFRABCG2 | |
| SCHEMBL8316202 | 0.80 | EGFR (0.55) | TRPV1EGFRABCG2TSHRKDM4E | |
| SCHEMBL5839044 | 0.78 | BRAF (0.54) | TRPV1CTSCAPPTP53POLB | |
| SCHEMBL12802767 | 0.77 | TRPV1 (0.51) | TRPV1EGFRABCG2CTSCAPP | |
| SCHEMBL25179790 | 0.76 | CTSC (0.73) | CTSC | |
| SCHEMBL658303 | 0.74 | CTSC (0.57) | CTSCAPPTP53POLBMAPT | |
| SCHEMBL16257538 | 0.74 | EGFR (0.61) | TRPV1EGFRABCG2CTSCAPP | |
| SCHEMBL23187344 | 0.74 | APP (0.51) | CTSCAPPTP53POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |