Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | CTSC | P53634 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257565 | 0.81 | EGFR (0.56) | EGFRABCG2TSHRHTTBRAF | |
| SCHEMBL3918204 | 0.78 | EGFR (0.69) | EGFRABCG2TSHRHTTBRAF | |
| SCHEMBL2100607 | 0.76 | EGFR (1.00) | EGFRABCG2TSHRBRAFLMNA | |
| SCHEMBL21159355 | 0.75 | EGFR (0.64) | EGFRABCG2TSHRHTTBRAF | |
| SCHEMBL8316388 | 0.74 | TRPV1 (0.52) | EGFRABCG2TSHRHTTTHRB | |
| SCHEMBL15033703 | 0.74 | MAPT (0.63) | EGFRABCG2LMNAMAPTMAPK1 | |
| SCHEMBL6918276 | 0.73 | NR4A1 (0.46) | EGFRHTTLMNAMAPTMAPK1 | |
| SCHEMBL28843677 | 0.72 | APP (0.65) | EGFRABCG2LMNAMAPTMAPK1 | |
| SCHEMBL30754777 | 0.72 | LMNA (0.65) | EGFRABCG2TSHRHTTTHRB | |
| SCHEMBL374140 | 0.70 | THRB (0.70) | EGFRABCG2TSHRHTTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |