Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.59 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.52 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.52 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316963 | 0.82 | EGFR (0.86) | EGFRAURKA | |
| SCHEMBL8871203 | 0.80 | EGFR (0.60) | EGFRPIP4K2APIP4K2CCD38 | |
| SCHEMBL8317980 | 0.79 | EGFR (0.65) | EGFR | |
| SCHEMBL8316727 | 0.79 | EGFR (0.73) | EGFRSYKAURKA | |
| SCHEMBL8317473 | 0.79 | EGFR (0.56) | EGFRSYKCDK1AURKA | |
| SCHEMBL8315008 | 0.75 | EGFR (1.00) | EGFR | |
| SCHEMBL8317851 | 0.75 | EGFR (0.77) | EGFR | |
| SCHEMBL8318451 | 0.75 | EGFR (0.77) | EGFR | |
| SCHEMBL8316429 | 0.74 | EGFR (0.80) | EGFR | |
| SCHEMBL8314630 | 0.74 | EGFR (0.66) | EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |