Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 5/20 | 0.53 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332914 | 0.85 | AVPR1A (0.62) | AVPR2AVPR1A | |
| SCHEMBL8316599 | 0.83 | AVPR2 (0.53) | AVPR2AVPR1AHSD11B1 | |
| SCHEMBL8316356 | 0.79 | AVPR1A (0.49) | AVPR2AVPR1A | |
| SCHEMBL8316512 | 0.78 | MEN1 (0.48) | AVPR2AVPR1A | |
| SCHEMBL8318107 | 0.78 | AVPR2 (0.65) | AVPR2AVPR1A | |
| SCHEMBL8557290 | 0.78 | AVPR2 (0.64) | AVPR2AVPR1A | |
| SCHEMBL7349942 | 0.77 | AVPR1A (0.68) | AVPR2AVPR1A | |
| SCHEMBL8318313 | 0.76 | AVPR2 (0.45) | AVPR2AVPR1A | |
| SCHEMBL8317666 | 0.76 | AVPR1A (0.46) | AVPR2AVPR1A | |
| SCHEMBL8314493 | 0.76 | AVPR2 (0.67) | AVPR2AVPR1AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968937-A | FOR TREATMENT AND/OR PREVENTION OF HYPERTENSION, CARDIAC INSUFFICIENCY, CORONARY VASOSPASM, CARDIAC ISCHEMIA, RENAL VASOSPASM, LIVER CIRRHOSIS, CONGESTIVE HEART FAILURE, NEPHROTIC SYNDROME, BRAIN EDEMA, CEREBRAL ISCHEMIA | AMERICAN CYANAMID COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0636625-B1 | Tricyclic diazepines vasopressin and oxytocin antagonists | AMERICAN CYANAMID CO (US) | 1999-01-27 | — | — | EP | disclosed |
| US-5516774-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN CYANAMID COMPANY (US) | 1996-05-14 | — | — | US | disclosed |
| EP-0636625-A2 | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-02-01 | — | — | EP | disclosed |