Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318976 | 0.95 | EGFR (0.54) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6989564 | 0.87 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6992426 | 0.84 | EGFR (0.53) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317835 | 0.81 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6992430 | 0.81 | EGFR (0.62) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6990337 | 0.80 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8315268 | 0.79 | EGFR (0.54) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318913 | 0.79 | EGFR (0.66) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6990967 | 0.79 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316641 | 0.78 | EGFR (0.57) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |