Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.41 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249992 | 0.86 | GPR35 (0.67) | AKR1B1TP53THRBMAOBLMNA | |
| SCHEMBL5730411 | 0.83 | AKR1B1 (0.56) | AKR1B1TP53THRBMAOBLMNA | |
| SCHEMBL19744109 | 0.82 | MAOB (0.54) | AKR1B1TP53THRBMAOBLMNA | |
| SCHEMBL19744064 | 0.81 | GPR35 (0.55) | AKR1B1TP53THRBMAOBLMNA | |
| SCHEMBL7628858 | 0.81 | AKR1B1 (0.47) | AKR1B1TP53THRBMAOBLMNA | |
| SCHEMBL8044054 | 0.79 | AKR1B1 (0.59) | AKR1B1TP53THRBMAOBGPR35 | |
| SCHEMBL4256577 | 0.77 | AKR1B1 (0.67) | AKR1B1MAOBSLC2A1MAPTKMT2A | |
| SCHEMBL4256024 | 0.77 | GPR35 (0.65) | AKR1B1MAOBLMNAGPR35MAPT | |
| SCHEMBL4253678 | 0.76 | GPR35 (0.63) | AKR1B1MAOBLMNAGPR35MAPT | |
| SCHEMBL5729570 | 0.76 | AKR1B1 (0.45) | AKR1B1TP53THRBMAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5750556-A | REDUCING DOPAMINE SYNTHESIS AND RELEASE, SCHIZOPHRENIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |