Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.53 |
| ▸ | CDK2 | P24941 | 7/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317377 | 1.00 | EGFR (0.58) | EGFRERBB2HPGDHTTCDK1 | |
| SCHEMBL7142831 | 0.95 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8316918 | 0.90 | EGFR (0.58) | EGFRERBB2HPGDHTTCDK1 | |
| SCHEMBL8460531 | 0.90 | EGFR (0.58) | EGFRERBB2HPGDHTTCDK1 | |
| SCHEMBL8316922 | 0.90 | EGFR (0.58) | EGFRERBB2HPGDHTTCDK1 | |
| SCHEMBL8320683 | 0.88 | EGFR (0.66) | EGFRERBB2HPGDHTT | |
| SCHEMBL8320678 | 0.88 | EGFR (0.66) | EGFRERBB2HPGDHTT | |
| SCHEMBL8313632 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTT | |
| SCHEMBL8313624 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTT | |
| SCHEMBL8317294 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |