Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DKK1 | O94907 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14011264 | 0.78 | MAPK1 (0.42) | EIF2AK2CDK2 | |
| SCHEMBL8317782 | 0.74 | EIF2AK2 (0.45) | EIF2AK2CDK2CDK4DYRK1ASYK | |
| SCHEMBL14011265 | 0.70 | MAPK1 (0.41) | EIF2AK2CDK2 | |
| SCHEMBL8318496 | 0.70 | CDK2 (0.53) | EIF2AK2CDK2CDK4SYK | |
| SCHEMBL14011270 | 0.69 | EIF2AK2 (0.48) | EIF2AK2CDK2 | |
| SCHEMBL8321179 | 0.67 | CDK4 (0.57) | EIF2AK2CDK2CDK4 | |
| SCHEMBL8318491 | 0.67 | NPSR1 (0.34) | EIF2AK2CDK2CDK4L3MBTL1CNR1 | |
| SCHEMBL28141529 | 0.64 | MAPK8 (0.44) | MAPK8CDC7DYRK1AKDM4EALDH1A1 | |
| SCHEMBL8320357 | 0.63 | CNR1 (0.34) | CDK2L3MBTL1CNR1ALDH1A1 | |
| SCHEMBL28071006 | 0.63 | POLB (0.54) | PTGS2MAPK8CDC7DYRK1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606284-B1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |