Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.45 |
| ▸ | CDK4 | P11802 | 10/20 | 0.45 |
| ▸ | CDK2 | P24941 | 10/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413081 | 0.87 | CDK4 (0.48) | EIF2AK2CDK4CDK2SYKJAK2 | |
| SCHEMBL4413076 | 0.87 | CDK4 (0.48) | EIF2AK2CDK4CDK2SYKJAK2 | |
| SCHEMBL4425029 | 0.84 | EIF2AK2 (0.46) | EIF2AK2CDK4CDK2SYKJAK2 | |
| SCHEMBL4425032 | 0.84 | EIF2AK2 (0.46) | EIF2AK2CDK4CDK2SYKJAK2 | |
| SCHEMBL14011298 | 0.83 | EIF2AK2 (0.48) | EIF2AK2CDK4CDK2SYKJAK2 | |
| SCHEMBL8321187 | 0.81 | NPSR1 (0.33) | CDK4SYKNPSR1 | |
| SCHEMBL14011247 | 0.79 | MAPK1 (0.43) | EIF2AK2CDK4CDK2MAPK1 | |
| SCHEMBL8318496 | 0.75 | CDK2 (0.53) | EIF2AK2CDK4CDK2SYKJAK2 | |
| SCHEMBL8321179 | 0.75 | CDK4 (0.57) | EIF2AK2CDK4CDK2JAK2NPSR1 | |
| SCHEMBL8317628 | 0.74 | EIF2AK2 (0.42) | EIF2AK2CDK4CDK2SYKDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |