Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 2/20 | 0.44 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317471 | 0.84 | EGFR (0.61) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8316240 | 0.84 | EGFR (0.69) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8317453 | 0.84 | EGFR (0.69) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8316032 | 0.83 | EGFR (0.72) | EGFRERBB2HPGDHTT | |
| SCHEMBL8317928 | 0.83 | EGFR (0.60) | EGFRERBB2HPGDHTTMKNK1 | |
| SCHEMBL8316916 | 0.83 | EGFR (0.55) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8319428 | 0.83 | EGFR (0.73) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL7142831 | 0.83 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8312571 | 0.83 | CSNK2A1 (0.60) | EGFRERBB2HPGDHTTFLT3 | |
| SCHEMBL8318827 | 0.83 | EGFR (0.57) | EGFRERBB2HPGDHTTFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |