Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 14/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316986 | 0.91 | ABCG2 (0.53) | ABCG2EGFRRAF1BRAF | |
| SCHEMBL8314074 | 0.89 | ABCG2 (0.55) | ABCG2EGFRRAF1BRAF | |
| SCHEMBL8312686 | 0.85 | ABCG2 (0.51) | ABCG2EGFRRAF1BRAF | |
| SCHEMBL8315550 | 0.85 | ABCG2 (0.51) | ABCG2EGFRRAF1BRAF | |
| SCHEMBL8315572 | 0.84 | EGFR (0.69) | EGFR | |
| SCHEMBL8317586 | 0.84 | EGFR (0.70) | EGFR | |
| SCHEMBL8315105 | 0.84 | ABCG2 (0.55) | ABCG2EGFRRAF1BRAF | |
| SCHEMBL8313472 | 0.84 | EGFR (0.53) | EGFR | |
| SCHEMBL8313676 | 0.82 | ABCG2 (0.53) | ABCG2EGFR | |
| SCHEMBL8317531 | 0.81 | EGFR (0.51) | ABCG2EGFRRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |