Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 14/20 | 1.00 |
| ▸ | MAOA | P21397 | 11/20 | 1.00 |
| ▸ | F12 | P00748 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11462954 | 0.95 | MAOB (0.91) | MAOBMAOAF12MAPK1NPC1 | |
| SCHEMBL4389144 | 0.90 | MAOA (1.00) | MAOBMAOAF12MAPK1NPC1 | |
| SCHEMBL4972712 | 0.90 | MAOB (1.00) | MAOBMAOAF12MAPK1GPR27 | |
| SCHEMBL6228344 | 0.89 | MAOB (1.00) | MAOBMAOAF12MAPK1NPC1 | |
| SCHEMBL14476486 | 0.89 | MAPK1 (1.00) | MAOBMAOAF12MAPK1NPC1 | |
| SCHEMBL6228552 | 0.86 | MAOB (1.00) | MAOBMAOAF12NPC1ADORA3 | |
| SCHEMBL8747311 | 0.86 | MAOB (0.75) | MAOBMAOAF12MAPK1ADORA3 | |
| SCHEMBL10980649 | 0.86 | CA1 (0.77) | MAOBMAOAF12MAPK1NPC1 | |
| SCHEMBL13936231 | 0.85 | MAOB (1.00) | MAOBMAOAF12NPC1RAB9A | |
| SCHEMBL28656523 | 0.85 | MAOB (1.00) | MAOBMAOAF12MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104925-A1 | CHROMONE DERIVATIVES FOR USE AS ANTIOXIDANTS/PRESERVATIVES | UNIVERSIDADE DO PORTO (PT) | 2008-09-04 | — | — | WO | claimed |
| US-8143428-B2 | Heteroaryl sulfones and sulfonamides and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-03-27 | — | — | US | disclosed |
| WO-2008104925-A1 | CHROMONE DERIVATIVES FOR USE AS ANTIOXIDANTS/PRESERVATIVES | UNIVERSIDADE DO PORTO (PT) | 2008-09-04 | — | — | WO | disclosed |
| US-20070232649-A1 | Heteroaryl Sulfones and Sulfonamides and Therapeutic Uses Thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-10-04 | — | — | US | disclosed |
| EP-1765804-A2 | HETEROARYL SULFONES AND SULFONAMIDES AND THERAPEUTIC USES THEREOF | Temple University of the Commonwealth System of Higher Education (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123077-A2 | HETEROARYL SULFONES AND SULFONAMIDES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232649-A1 | Heteroaryl Sulfones and Sulfonamides and Therapeutic Uses Thereof | SULT1E1, STS, CCNE1 | MAOB 4108/4885MAOA 4650/4885F12 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.