Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyprazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | GHSR | Q92847 | 3/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyprazepam SCHEMBL30736035 | 0.83 | CYP1A2 (0.56) | CYP1A2CHRM1KDM4E | |
| Cyprazepam SCHEMBL114194 | 0.83 | CYP1A2 (0.56) | CYP1A2CHRM1KDM4E | |
| Cyprazepam SCHEMBL29040984 | 0.82 | CYP1A2 (0.56) | CYP1A2CHRM1KDM4E | |
| Desipramine SCHEMBL7763271 | 0.76 | CYP3A4 (0.47) | CYP1A2SLC6A2CYP3A4CHRM1DRD2 | |
| Cyprazepam SCHEMBL8350722 | 0.74 | CYP1A2 (0.53) | CYP1A2CHRM1CHRM3CHRM2KDM4E | |
| Chlordiazepoxide SCHEMBL29358041 | 0.72 | CYP1A2 (0.60) | CYP1A2CYP3A4HTR2CADRA1AOPRK1 | |
| Chlordiazepoxide SCHEMBL10887473 | 0.72 | CYP1A2 (0.60) | CYP1A2CYP3A4HTR2CADRA1AOPRK1 | |
| SCHEMBL28910535 | 0.71 | CYP1A2 (0.59) | CYP1A2MAPK1SMN1; SMN2KDM4ETP53 | |
| Chlordiazepoxide SCHEMBL5446390 | 0.71 | CYP1A2 (0.59) | CYP1A2CYP3A4HTR2CADRA1AOPRK1 | |
| Chlordiazepoxide SCHEMBL5974493 | 0.71 | CYP1A2 (0.59) | CYP1A2CYP3A4HTR2CADRA1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906315-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049710-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-12-31 | — | — | WO | disclosed |