SCHEMBL8318593

SCHEMBL8318593

NC(=O)Nc1ccc(C=C2C(=O)Nc3ncccc32)cc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
APP P05067 2/20 0.60
MAPT P10636 2/20 0.60
SNCA P37840 2/20 0.60
CTRC Q99895 1/20 0.53
PDK1 Q15118 2/20 0.46
RAF1 P04049 1/20 0.45
NTRK1 P04629 1/20 0.45
AKT2 P31751 3/20 0.44
PDPK1 O15530 2/20 0.44
LRRK2 Q5S007 1/20 0.43
RET P07949 4/20 0.42
GSK3B P49841 4/20 0.41
PIM1 P11309 1/20 0.41
FLT3 P36888 1/20 0.40
PLK4 O00444 1/20 0.40
PDGFRB P09619 1/20 0.40
PLK1 P53350 1/20 0.40
MAP3K11 Q16584 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8324008 0.89 MAPT (0.59) APPMAPTSNCACTRCRAF1
SCHEMBL8465798 0.82 APP (0.54) APPMAPTSNCACTRCRAF1
SCHEMBL8325317 0.81 MAPT (0.70) APPMAPTSNCACTRCRAF1
SCHEMBL8321070 0.81 MAPT (0.70) APPMAPTSNCACTRCRAF1
SCHEMBL8320714 0.81 MAPT (0.62) APPMAPTSNCACTRCRAF1
SCHEMBL8321242 0.80 MAPT (0.65) APPMAPTSNCACTRCRAF1
Hydrochloric Acid SCHEMBL8318774 0.80 MAPT (0.68) APPMAPTSNCACTRCRAF1
Hydrochloric Acid SCHEMBL8320058 0.80 MAPT (0.61) APPMAPTSNCACTRCRAF1
SCHEMBL8320786 0.79 PDK1 (0.47) APPMAPTSNCACTRCPDK1
SCHEMBL8319519 0.79 MAPT (0.63) APPMAPTSNCACTRCRAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0741726-B1 SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN SPA (IT) 1999-11-17 EP claimed
EP-0741726-A1 SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN S.p.A. (IT) 1996-11-13 EP claimed
WO-1996016964-A1 SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN S.P.A (IT) 1996-06-06 WO claimed
EP-0741726-B1 SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN SPA (IT) 1999-11-17 EP disclosed
US-5719135-A TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1998-02-17 US disclosed
EP-0741726-A1 SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN S.p.A. (IT) 1996-11-13 EP disclosed
WO-1996016964-A1 SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN S.P.A (IT) 1996-06-06 WO disclosed