Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.79 |
| ▸ | CD38 | P28907 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319624 | 0.90 | EGFR (0.78) | EGFRCD38HTTHIF1AMAPK1 | |
| SCHEMBL8317769 | 0.89 | EGFR (1.00) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8316000 | 0.84 | EGFR (0.79) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8314812 | 0.84 | EGFR (0.79) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8318687 | 0.83 | EGFR (0.77) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8316168 | 0.81 | EGFR (1.00) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8316955 | 0.81 | EGFR (0.72) | EGFRHTTHIF1A | |
| SCHEMBL8316963 | 0.80 | EGFR (0.86) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8318926 | 0.80 | EGFR (0.71) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8317470 | 0.80 | EGFR (0.77) | EGFRHTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |