Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1415779 | 0.76 | KMT2A (0.58) | KDM4ELMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL15882934 | 0.76 | KDM4E (0.37) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL28754732 | 0.76 | KDM4E (0.38) | KDM4ELMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28018343 | 0.71 | NPY5R (0.59) | KDM4ESMN1; SMN2HTTMAPTNPSR1 | |
| SCHEMBL24175003 | 0.71 | KDM4E (0.61) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8325338 | 0.71 | KDM4E (0.74) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL29532939 | 0.71 | KDM4E (0.74) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL31392367 | 0.69 | KDM4E (0.59) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8483152 | 0.69 | KDM4E (0.59) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3816236 | 0.69 | KDM4E (0.59) | KDM4ELMNASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594883-B1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NAT SCIENCE COUNCIL (TW) | 1999-01-27 | — | — | EP | disclosed |
| US-5512677-A | TREATING HYPERTENSION, DYSURIA | NATIONAL SCIENCE COUNCIL (TW) | 1996-04-30 | — | — | US | disclosed |
| US-5340814-A | Hypotensive agents | NATIONAL SCIENCE COUNCIL (TW) | 1994-08-23 | — | — | US | disclosed |
| EP-0594883-A1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |