Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.74 |
| ▸ | MAPT | P10636 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 5/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29532939 | 1.00 | KDM4E (0.74) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL24175003 | 0.80 | KDM4E (0.61) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8483152 | 0.78 | KDM4E (0.59) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL31392367 | 0.78 | KDM4E (0.59) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8810477 | 0.78 | KDM4E (0.59) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL3816236 | 0.78 | KDM4E (0.59) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL20115757 | 0.78 | CYP1A2 (0.58) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11165369 | 0.78 | L3MBTL1 (0.56) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL20203648 | 0.77 | KDM4E (0.67) | KDM4EMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL31736049 | 0.74 | ALDH1A1 (0.55) | KDM4EMAPTALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276302-B | Method for preparing 2, 4-diaminoquinazoline derivative | 山东百启生物医药有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-114276302-A | Method for preparing 2, 4-diamino quinazoline derivative | 山东百启生物医药有限公司 | 2022-04-05 | — | — | CN | disclosed |
| US-5932584-A | ADMINISTERING TO TREAT UROGENITAL DISORDERS; AMINATION, DECYCLIZATION, CYCLIZATION | NATIONAL SCIENCE COUNCIL (TW) | 1999-08-03 | — | — | US | disclosed |
| EP-0594883-B1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NAT SCIENCE COUNCIL (TW) | 1999-01-27 | — | — | EP | disclosed |
| US-5512677-A | TREATING HYPERTENSION, DYSURIA | NATIONAL SCIENCE COUNCIL (TW) | 1996-04-30 | — | — | US | disclosed |
| US-5340814-A | Hypotensive agents | NATIONAL SCIENCE COUNCIL (TW) | 1994-08-23 | — | — | US | disclosed |
| EP-0594883-A1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |